In our family studies, it is obvious that patients with neurotic-reactive depres­sion have a low morbidity risk of bipolar affective disorders in their first-degree relatives (Table 4) (13). Thus both neurotic-reactive depression and unipolar affective disorders seem to be distinct categories from bipolar affective disorders as concerns family studies. Furthermore, there is no significant difference in morbidity risk for alcoholism or schizophrenia between the first-degree relatives of patients with neurotic-reactive depression and patients with unipolar affective disorders. The only significant difference found is a significantly higher morbidity risk for nonbipolar affective disorders in the first-degree relatives of patients with unipolar affective disorders, as compared to the first-degree relatives of patients with neurotic-reactive depression. The results seem to indicate a higher genetic component in unipolar affective disorders than in patients with neurotic-reactive depression. The results are comparable to results from other studies presented earlier (Table 5) (13).

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