1. Altamura, A. C, Mauri, M. C, and Guercetti, G. (1986): Prog. Neuropsychopharmacol. Biol Psychiatry, 10:67-75. 2. Altamura, A. C, Melorio, Т ., Colombo, G, and Cazzullo, С L. (1984): Clin. Neuropharmacol. 7(Suppl. 1):850-851. 3. Altamura, A. C, Melorio, Т ., Invernizzi, G., and Gomeni, R. (1982): Psychopharmacology, 78: 380-382. 4. Cazzullo, С L., and Altamura, A. C. (1985): Integr. Psychiatry, 3:50S-57S. 5. Grimsson, A., Idanpaan-Heikkila, J., Lunde, P. K., Olafsson, O., and Westerholm, B. (1977): Nord. Med., 92:49-54. 6. Lopez-Ibor, J. J. Jr. (1950): In: La angustia vital. Paz Montalvo, Madrid. 7. Lopez-Ibor, J. J. Jr. (1985): Psychopathology, 18:133-139. 8. Millard, P. H. (1983): Br. Med. J., 287:375-376. 9. Post, F. (1976): In: Depression: Behavioral, Biochemical Diagnostic and Treatment Concepts, edited by D. M. Gallant and G. M. Simpson, pp. 205-231. Spectrum Publications Inc., New York. 10. Weitbrecht, H. J. (1963): Psychiatrie im Grundriss. Springer, Berlin. 11. West, E. D., and Dally, P. J. (1959): Br. Med. J., Ы 491-1494. (more…)

Subjects
A total of 152 psychiatric outpatients have been accepted and randomly as­signed to treatments. Their mean age was 38, and mean age at onset of the disorder was 28. Male-to-female ratio was 41%-to-59%. Other sample charac­teristics are shown in Table 1. (more…)

Institute of Clinical Psychiatry, Milan Medical School, Ospedale S. Paolo, 20142 Milan, Italy
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Three clinical research studies using alprazolam for the treatment of a spectrum of anxiety/depression disorders have been described. Experience indicates that a substantial number of patients suffer from combined syndromes of anxiety and depression, and the results of these studies show that alprazolam was clinically effective across the spectrum of anxious depression disorders.

This work was supported in part by an NIMH Research Scientist Development Award (MH-00508) to Dr. Pauls.
REFERENCES (more…)